Retatrutide is a fatty acid acylated single peptide, a peptide compound with triple agonist activity, also known as a GGG triple agonist. It can act on GLP-1R, GIPR and GCGR simultaneously, combining the glucagon receptor agonism with the GIP and GLP-1 receptor agonism. GLP-1 and GIP, as incretin hormones, can promote insulin secretion, produce satiety, and reduce appetite, while GCG can promote energy consumption and increase lipid metabolism.