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Cetrorelix acetate

Name
Cetrorelix acetate
Molecular structural formula
CAS Number
145672-81-7
Formula
C72H96ClN17O16
MW
1491.09
Sequence Shortening
Ac-{D-2Nal}-{D-Phe(4-Cl)}-{D-3Pal}-SY-{D-Cit}-LRPa-NH2.CH3CO2H
Sequence
Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2.CH3CO2H
InChIKey
KFEFLCOCAHJBEA-ANRVCLKPSA-N
DMSO solubility
50 mg/mL
Solubility in water
2 mg/mL
Purity
≥98%
References
[1]. Beckers T et al. Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. Anal Biochem. 1997 Aug 15;251(1):17-23. [2]. Gründker C et al. Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod Biol Endocrinol. 2003 Oct 7;1:65.
Target
GnRH Receptor
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Product details
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Cetrorelix acetate is a synthetic polypeptide GnRH antagonist composed of 6 amino acids. It inhibits the secretion of luteinizing hormone and follicle-stimulating hormone by competitively binding to pituitary GnRH receptors and usually exists in the form of acetate.