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Linaclotide

Name
Linaclotide
Molecular structural formula
CAS Number
851199-59-2
Formula
C59H79N15O21S6
MW
1526.74
Sequence Shortening
CCEYCCNPACTGCY(Disulfide bridge: Cys1-Cys6;Cys2-Cys10;Cys5-Cys13;)
Sequence
Cys(1)-Cys(2)-Glu-Tyr-Cys(3)-Cys(1)-Asn-Pro-Ala-Cys(2)-Thr-Gly-Cys(3)-Tyr
InChIKey
KXGCNMMJRFDFNR-WDRJZQOASA-N
DMSO solubility
50 mg/mL
Solubility in water
16.67 mg/mL
Purity
≥98%
References
[1]. Bryant AP, et al. Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract. Life Sci. 2010 May 8;86(19-20):760-5. [2]. Love BL, et al. Linaclotide: a novel agent for chronic constipation and irritable bowel syndrome. Am J Health Syst Pharm. 2014 Jul 1;71(13):1081-91.
Target
Guanylate Cyclase
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Product details
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Linaclotide is a 14-amino acid guanylate cyclase C (GC-C) agonist. Its mechanism of action involves binding to GC-C in the intestine, thereby increasing the concentration of intracellular cyclic guanosine monophosphate (cGMP) and promoting intestinal fluid secretion, thereby exerting its biological activity.