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Tumor Antigen Peptide (Customized)

Liraglutide

Name
Liraglutide
Molecular structural formula
CAS Number
204656-20-2
Formula
C172H265N43O51
MW
3751.20
Sequence Shortening
HAEGTFTSDVSSYLEGQAA-{K(Pal-γ-Glu)}-EFIAWLVRGRG
Sequence
His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-{Lys(Pal-γ-Glu)}-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly
Solubility in water
9.52 mg/mL
Purity
≥99%
References
[1]. Wang Y,et al. Transformation of oligomers of lipidated peptide induced by change in pH.Mol Pharm. 2015 Feb 2;12(2):411-9. [2]. Wang YG, et al. Liraglutide reduces oxidized LDL-induced oxidative stress and fatty degeneration in Raw 264.7 cells involving the AMPK/SREBP1 pathway.J Geriatr Cardiol. 2015 Jul;12(4):410-416.
Target
GCGR
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Product details
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Liraglutide is a glucagon-like peptide-1 receptor agonist. Its sequence is modified based on human GLP-1 (7-36) amide by replacing arginine at position 34 with lysine and connecting a hexadecanoic acid chain to lysine at position 26. It can promote insulin secretion, inhibit glucagon release and delay gastric emptying by stimulating the GLP-1 receptor.