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Plecanatide

Name
Plecanatide
Molecular structural formula
CAS Number
467426-54-6
Formula
C65H104N18O26S4
MW
1681.89
Sequence Shortening
NDECELCVNVACTGCL (Disulfide bridge: Cys4-Cys12; Cys7-Cys15)
Sequence
Asn-Asp-Glu-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu (Disulfide bridge: Cys4-Cys12; Cys7-Cys15)
InChIKey
NSPHQWLKCGGCQR-DLJDZFDSSA-N
DMSO solubility
100 mg/mL
Purity
≥98%
References
[1]. Shailubhai K,et, al. Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis. World J Gastrointest Pharmacol Ther. 2015 Nov 6;6(4):213-22. [2]. Rao SSC. Plecanatide: a new guanylate cyclase agonist for the treatment of chronic idiopathic constipation. Therap Adv Gastroenterol. 2018 Jun 8;11:1756284818777945. [3]. Shailubhai K, et, al. Plecanatide, an oral guanylate cyclase C agonist acting locally in the gastrointestinal tract, is safe. Dig Dis Sci. 2013 Sep;58(9):2580-6.
Target
Guanylate Cyclase
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Product details
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Plecanatide is an orally active synthetic peptide drug of the guanylate cyclase C receptor agonist class that promotes the production of cyclic guanosine monophosphate by activating intestinal epithelial GC-C receptors, increasing intestinal fluid secretion and softening stool.