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Synthesis of unnatural amino acids and other blocks

Sinapultide

Name
Sinapultide
Molecular structural formula
CAS Number
138531-07-4
Formula
C126H238N26O22
MW
2469.4
Sequence Shortening
KLLLLKLLLLKLLLLKLLLL
Sequence
Lys-Leu-Leu-Leu-Leu-Lys-Leu-Leu-Leu-Leu-Lys-Leu-Leu-Leu-Leu-Lys-Leu-Leu-Leu-Leu
InChIKey
QSIRXSYRKZHJHX-TWXHAJHVSA-N
Purity
≥98%
References
[1]. Braide-Moncoeur O, et al. Peptide-based synthetic pulmonary surfactant for the treatment of respiratory distress disorders. Curr Opin Chem Biol. 2016 Jun;32:22-8. [2]. Liu D, et al. Sinapultide-Loaded Microbubbles Combined with Ultrasound to Attenuate Lipopolysaccharide-Induced Acute Lung Injury in Mice. Drug Des Devel Ther. 2020 Dec 22;14:5611-5622.
Target
Biochemical Assay Reagents
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Product details
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Sinaputide is a synthetic 21-mer peptide, the sequence of which contains only two amino acids, Lys and Leu. The design of this drug is inspired by human pulmonary surfactant protein B (SP-B), which can bind to phospholipid surfactants to enhance their efficacy.