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Synthesis of unnatural amino acids and other blocks

GLP-1 (7-37)

Name
GLP-1 (7-37)
Molecular structural formula
Purity
≥98%
CAS Number
106612-94-6
Formula
C151H228N40O47
MW
3355.67
Target
GCGR
Sequence
H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-OH (trifluoroacetate salt)
Sequence Shortening
HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG
Solubility in water
< 0.1 mg/mL
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Product details
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Glucagon-like peptide-1 (GLP-1) is a hormone secreted by intestinal L cells, and its receptor agonist (GLP-1RA) is an innovative hypoglycemic drug. It lowers blood sugar levels through multiple mechanisms such as promoting insulin secretion, inhibiting the release of glucagon, delaying gastric emptying, and reducing food intake. In addition, GLP-1RA can improve blood lipids, blood pressure, liver enzyme activity and liver fat content, enhance insulin sensitivity, and provide protection for the cardiovascular system and kidneys.